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KMID : 1134820090380091161
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 9 p.1161 ~ p.1166
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Effect of Red Pepper Seeds Powder on Antioxidative System and Oxidative Damage in Rats Fed High-Fat?High-Cholesterol Diet
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Song Won-Young
Yang Jeong-Ah
Ku Kyung-Hyung
Choi Jeong-Hwa
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Abstract
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The purpose of the present study was to effect of red pepper seeds powder on antioxidative defense system and oxidative damage in rats fed high fat?high cholesterol diet. Rats were divided into five experimental groups which are composed of normal diet group, high fat?high cholesterol diet group, high fat?high cholesterol diet with 5% red pepper seeds powder supplemented group (SA group), high fat?high cholesterol diet with 10% red pepper seeds powder supplemented group (SB group), and high fat?high cholesterol diet with 15% red pepper seeds powder supplemented group (SC group). Supplementation of red seed pepper groups (SA, SB, and SC groups) resulted in increased activities of hepatic glutathione peroxidase and superoxide dismutase. However, there was no significant difference in the activity of hepatic catalase among all experimental groups. Hepatic superoxide radical contents in microsome and mitochondria were significantly reduced in red pepper seeds powder supplemented groups. Hepatic hydrogen peroxide contents in mitochondria were significantly reduced 15% red pepper seeds powder supplemented group. Hepatic carbonyl values in microsome were significantly reduced in 10% and 15% red pepper seeds powder supplemented groups. Thiobarbituric acid reaction substance (TBARS) values in liver and plasma were reduced in red pepper seeds powder supplemented groups. These result suggest that red pepper seeds powder may reduce oxidative damage by the activation of antioxidative defense system in rats high fat?high cholesterol diets.
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KEYWORD
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red pepper seeds powder, antioxidative system, high cholesterol, oxidative damage, free radical
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